The monograph is devoted to the problem of asymmetrical development of region and municipalities included in its structure. The author carried out the complex analysis of conceptual foundations for the improvement of regional and local policies in terms of asymmetrical territorial development; devised a new methodology for estimating the level of asymmetry in sub-regional territories; and developed the adjustment mechanism of the regional and local politics. The monograph can be useful to regional and municipal authorities, representatives of business community, wide audience of readers who are interested in the development of territories.